Association of ustekinumab and briakinumab with major adverse cardiovascular events: An appraisal of meta-analyses and industry sponsored pooled analyses to date.

did not detect a statistical significant increase using the Mantel-Haenszel fixed-effects model with absolute risk differences as an effect measure, although their findings approached significance (p = 0.11). 1 In contrast, Tzellos et al. detected a statistically significant increase in cardiovascular risk using the Peto method (p = 0.04), which excluded studies with zero events. 2 An astute reader may wonder how there could be divergent results between these two meta-analyses which essentially use the same data.

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One detected statistically significant increase in cardiovascular risk using Peto method (p = 0.04), while the other utilized Mantel-Haenszel fixed-effects model with absolute risk differences as effect measure, but did not achieve significance (p = 0.11).

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