The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.

ES-62 also tended to reduce the numbers of macrophages and total cells in the BAL fluid (BALF) but this did not reach statistical significance ( Fig. 1 D, E). 3.2 ES-62 suppression of lung inflammation is associated with reduced local Th2 cytokine responses To address whether such protection reflects immunomodulation of polarised Th responses during OVA-induced airway inflammation, the effect of in vivo exposure to ES-62 on subsequent peribronchial DLN recall responses to OVA ex vivo was determined.

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