Other researchers have noted the limited survival benefits observed in some bevacizumab studies, whereby addition of bevacizumab to oxaliplatin-based chemotherapy significantly improved progression-free survival (PFS); however, OS differences did not reach statistical significance nor was response rate improved [ 32 ], whilst some preclinical and clinical studies have reported that VEGF inhibition actually increased tumour invasiveness and metastasis, suggesting that bevacizumab may indirectly stimulate new blood vessel growth (and tumour dissemination) through a VEGF-independent mechanism [ 33 , 34 ].
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