The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.

After 11 days of continuous DSS administration, treatment with 5 mg/kg/d pumafentrine showed a tendency to decrease the histologic score compared to the 4% methocel-treated group, an effect that did not reach statistical significance ( Figure 4C ) .

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