Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits.

Drug Healthc Patient Saf · 2013 · PMC3585507 · PMID 23459383

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failed to reach statistical significanceno p-value reported

The proportion of patients with disease progression was reduced significantly in DEFINE but failed to reach statistical significance in CONFIRM. 44 , 45 Secondary clinical endpoints and MRI measures of disease activity, including the number of Gd-enhancing lesions and T2-weighted hyperintense lesions, favored BG-12 over placebo as well.

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