Cardiovascular safety of anagrelide in healthy subjects: effects of caffeine and food intake on pharmacokinetics and adverse reactions.

There were no clinically significant changes in laboratory safety tests, vital signs or physical examination during the study. Palpitations Palpitations occurred in more individuals during the fed/caffeine period (12/34 subjects, 35 %) than during the fasted period, although the difference did not reach statistical significance (6/35, 17 %; p = 0.09).

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