Barely Significant
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Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?

PLoS One · 2013 · PMC3591301 · PMID 23505498

Europe PMCDOI
2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

borderline significantP = 0.06so close (0.05 < p ≤ 0.1)
The average PPARGC1A methylation at four CpG sites situated 867-624 bp from the transcription start was associated with whole-body insulin sensitivity in a paradoxical positive manner (β = 0.12, P = 0.03), supported by a borderline significant inverse correlation with fasting insulin levels (β = −0.88, P = 0.06).

also in 11,409 other papers

showed a trendno p-value reported
, DNA methylation in a region of the PPARGC1A promoter located 867-624 base pairs (bp) upstream from the transcription start was higher in T2D patients, and furthermore showed a trend towards an inverse correlation with gene expression in pancreatic islets [25] .

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.