Although the difference in the number of progeny with Frem1 eyes2/+ and Frem1 eyes2/eyes2 genotypes did not reach statistical significance (77/214 vs. 61/214, p = 0.173), a statistically significant decrease was seen between the number of progeny with a Frem1 eyes2/+ ; Gata4 +/− genotype and the number of progeny with a Frem1 eyes2/eyes2 ; Gata4 +/− genotype (47/214 vs. 29/214, p = 0.039).
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Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.
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