As shown, compared with the luciferase activity of PTB-overexpressing cells receiving pGL3-promoter, the luciferase activity of PTB-overexpressing cells receiving pGL3-B2 was approximately 44% higher, whereas the luciferase activity of control cells receiving pGL3-B2 was slightly higher than that of control cells receiving pGL3-promoter, but the increase did not reach statistical significance ( Fig. 9A ).
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Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells.
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