Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA.

Transl Psychiatry · 2013 · PMC3594731 · PMID 23423139

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showed a trendP =0.08so close (0.05 < p ≤ 0.1)

In comparing data from Def-Sz, Non-Def-Sz and controls, levels of miR-107 (F=4.25, d.f.=2,40, P =0.02) and [ 3 H] pirenzepine binding (F=72.3, d.f.=2,40, P <0.0001) varied with group, levels of CHRM1 mRNA showed a trend to varying with group (F=2.68, d.f.=2,40, P =0.08) whereas levels of miR-16 did not vary with group (F=0.65, d.f.=2,40, P =0.52) ( Figures 2c and d ).

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