Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

The effect size ratio is highly significant (OR 1.60, 95% CI 1.27 to 2.02, p=7.36×10 −5 ).

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A large meta-analysis, across four European populations, found only a weakly significant association between several HLA alleles and anti-CCP negative RA, but observed marked geographical differences. 12 Lack of consistency between studies might therefore be explained by a different sample size and power, by geographical differences in allele frequencies and association patterns or by different study designs or definitions of HLA genotypes (two vs four-digit typing, different classifications for the SE).

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