MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.

Nucleic Acids Res · 2013 · PMC3597665 · PMID 23314153

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a significant trendno p-value reported

Indeed, we detected a significant trend towards longer GC tracts, most notably in PMS2-deficient cells, which confirms that MMR affects resolution of the heteroduplex intermediates arising during Ig GC ( 46 , 47 , 79 ).

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