The increase in type-1 response may be partly related to modulation of T reg cells: mRCC patients were found to have a significantly higher number of T reg than healthy controls, and while an inverse correlation between the increase in type-1 and a decrease in the percentage of T reg was noted, the reduction in T reg after treatment did not reach statistical significance (Finke et al., 2008 ).
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Clinical perspectives on targeting of myeloid derived suppressor cells in the treatment of cancer.
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