Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.

Combined analysis of all samples investigated (2,966 cases, 10,556 comparison subjects) produced highly significant evidence that duplications at 15q13.3 are associated with ADHD (p=0.000178; odds ratio=2.22, 95% confidence interval=1.46–3.38).

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While post hoc analyses failed to reveal any significant evidence that overall CNV carriership was associated with ADHD subtype, ADHD symptom dimension, or presence of oppositional defiant disorder, we did observe a nominally significant association (p=0.03 uncorrected) between conduct disorder and carriers of 15q13.3 duplications.

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