De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

Mol Psychiatry · 2012 · PMC3603134 · PMID 22083728

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0200

boldest claim

The sentences

highly significantP =1.72 × 10 −6actually significant

Compared with Bulgarian control CNVs, we found a highly significant excess of PSD genes within case de novos ( P =1.72 × 10 −6 ; Table 2 ).

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nominally significantP =0.02actually significant

However, nominally significant associations ( P uncorrected <0.05) were observed for deletions at DLG2 ( P =0.02) and MSRA ( P =0.03), whereas the EHMT1 locus just failed to reach this uncorrected threshold ( P =0.055).

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