Accumulation of cadmium in insulin-producing β cells.

Effect of Cd exposure on glucose stimulated insulin secretion in MIN6 cells In static incubation experiments, exposure of MIN6 cells to CdCl 2 concentrations of 0.1, 0.5 and 1.0 μmol/L for 48 h only showed a trend toward a concentration dependent decrease in glucose stimulated insulin secretion (GSIS) with GSIS ratios of 5.6 ± 0.8, 2.8 ± 1.0 and 1.4 ± 0.1, respectively, compared with 5.6 ± 0.6 in the control (p < 0.05 for 1.0 μmol/L CdCl 2 compared with control, Fig. 3A ).

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P values ≤ 0.05 and 0.005 were considered statistically significant and highly significant respectively.

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