Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state.

PLoS One · 2013 · PMC3605453 · PMID 23555645

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Overall, GI-MEN clones showed a trend towards higher chromosome copy number diversity than SK-N-AS clones (mean 14% compared to 8% of cells with copy number outside the modal value; p = 0.05), consistent with the higher rate of mitotic segregation errors in the former cell line.

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