Finally, change in JAK2 V617F genotype during follow-up was associated with an increased risk of BT, which however did not reach statistical significance (HR 2.45, 95% CI, 0.89–6.71; P = 0.08) in a bivariable analysis including JAK2 V617F status at diagnosis.
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JAK2 V617F genotype is a strong determinant of blast transformation in primary myelofibrosis.
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