Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants.

Neither wortmannin, LY294002, A66, nor ZSTK474 (each tested at 1–10 μM) increased the lifespan of wild-type worms (Table 1 ), However, GDC-0941 – reportedly the most avid p110α inhibitor – at 1 μM extended lifespan by 10% (nominally significant, Gehans–Wilcoxon P < 0.03).

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