Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

For ER- breast cancer (n = 441 cases) many associations (358) with very rare SNPs were nominally significant using the score test but the p-values failed to stand up to further investigation using exact logistic regression (the exact p-values ranged from 3×10 −5 to 0.21).

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Previous reports [24] , [39] have highlighted the NS SNP rs17632542 in KLK3 as highly associated with PSA level and a highly significant risk variant in fine-mapping of the locus near rs2735839 [39] ; while no report for prostate cancer exists for coding SNPs in RTEL1 , another NS SNP, rs3208008, in RTEL1 has been found to be associated with glioma risk [40] .

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