Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy.

Although the data from the four separate TIL lines were not statistically significant due to the different intrinsic apoptosis sensitivities of each line, there was a clear trend towards a decrease in Annexin V + cells in each case with TIL from the 4-1BB REP cultures (IL-2+4-1BB) versus control REP cultures (IL-2) when the post-REP cells were re-plated without IL-2 or with added IL-2 ( Figure 7D ). 4-1BB Co-stimulation during the REP Enhances Responsiveness of MART-1 Specific TIL to Antigen Re-stimulation Previously, we reported that MART-1-specific CD8 + T cells that lose CD28 become hypo-responsive to antigenic re-stimulation by peptide-pulsed DC following the REP.

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