New players for advanced prostate cancer and the rationalisation of insulin-sensitising medication.

Int J Cell Biol · 2013 · PMC3614121 · PMID 23573093

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highly significantno p-value reported

However, it is hyperinsulinaemia, as a result of insulin resistance in classical metabolic tissues, which has been identified as a highly significant risk factor to progression of prostate and other cancers [ 14 ].

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a strong trendno p-value reported

Major findings from recent studies [ 36 , 143 ] and our own recent pilot study of men receiving ADT demonstrated a strong trend between elevated C-peptide and more rapid progression to CRPC.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.