SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.

Highly significant results were obtained for SORL1 SNPs rs4598682 ( P = 9.51×10 −6 ), rs3781834 ( P = 7.33×10 −7 ), rs17125523 ( P = 5.51×10 −6 ), and rs3737529 ( P = 4.14×10 −6 ) after combining results from the discovery and replication samples ( Table S3 ).

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SNPs with a P value below 1×10 −5 in the combined Stages 1 and 2 samples and nominally significant in Stage 2 ( P <0.05) were advanced to Stage 3.

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