Although the difference in the amounts of the NS gene in the one-step grown virions did not reach statistical significance ( Fig. 4C ), there was a statistical difference in the amount of GFP-vRNA between WT- and C1620A-VLPs ( Fig. 5B ), suggesting that CM2 oligomerization affects genome packaging efficiency.
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Effect of cysteine mutations in the extracellular domain of CM2 on the influenza C virus replication.
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