Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC.

J Transl Med · 2013 · PMC3618083 · PMID 23320561

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did not reach statistical significanceno p-value reported

However, this did not reach statistical significance and may be a reflection of the relatively small numbers (n = 16) used for the mRNA analysis.

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