Systematic identification of combinatorial drivers and targets in cancer cell lines.

CDKN2A and EZH2, CTNNB1 and MYC, IDH1 and PTEN, and NRAS and TET2 showed a trend toward mutual exclusivity (P = 0.081 for all).

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Expected and observed co-event frequency were generated in the sensitive and resistant cell lines and genomic co-features that were in disequilibrium captured through multi-layered statistical and biological significance testing and cross validation thus producing highly significant co-selected and mutually exclusive events including genomic and lineage features in the cell line population and for each drug ( Fig. 2 ).

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