Modification of the FoxP3 transcription factor principally affects inducible T regulatory cells in a model of experimental autoimmune encephalomyelitis.

In the spleen, the frequency of FoxP3 expression by CD4 + T cells showed a trend towards lower expression in mice carrying the GFP-FoxP3 transgene ( Figure 1A ), yet the absolute number of CD4 + FoxP3 + cells in the spleen did not change significantly ( Figure 1B ).

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