Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit.

IL-6, another pro-inflammatory cytokine, also tended to be lower in all CR groups but in the curcumin + piperine group only, this decrease reached significance while in all the other CR groups, there was a strong trend toward decreases with varied p values at 0.06 to 0.08 (Figure 4 C).

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