Major side effects of arzoxifene include VTE (a side effect common among all agents with any estrogen receptor agonist effects), hot flushes, muscle cramps, vaginal discharge, vulvovaginitis, and increased reports of endometrial cancer and hyperplasia, though the last two failed to reach statistical significance [ 185 ].
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The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice.
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