Mitotic spindle defects and chromosome mis-segregation induced by LDL/cholesterol-implications for Niemann-Pick C1, Alzheimer's disease, and atherosclerosis.

We observed a 4-fold increase in trisomy 21 in NPC1 fibroblasts ( Figure 2A,B ) compared to normal fibroblasts and an increase of aneuploidy 12 that did not reach statistical significance (2.1% versus 0.4%, p = 0.12).

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The chromosome specific aneuploidy was further analyzed by quantitative FISH ( Figure 3B–E ), which revealed an induction of: 1) trisomy 21 and 12 by OX-LDL and a borderline significant induction of trisomy 21 and 12 by LDL ( Figure 3B and D ), and 2) induction of tetrasomy 21 and 12 by both OX-LDL and/or LDL ( Figure 3C and E ).

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