Decreased frontal regulation during pain anticipation in unmedicated subjects with major depressive disorder.

As expected, there was highly significant effect of temperature (or temperature cue), whereby high temperature resulted in higher rating of anticipatory anxiety (F (1, 49)=57.9; P <0.000), pain intensity (F (1, 49)=100.1; P <0.000) and pain unpleasantness (F (1, 48)=73.783; P <0.000).

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Furthermore, the between-group difference in the strengths of these correlations was significant for pain intensity ( z =−2.16; P <0.05) and approached significance for pain unpleasantness ( z =−1.72; P =0.08) rating.

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