Also, although it did not reach statistical significance, LAMP1 and LAMP2A were found to be upregulated under chronic oxidative stress in all the cell lines tested ( LAMP1 : 1.849 ± 0.345 fold, p = 0.091, n = 4; LAMP2A : 1.987 ± 0.392 fold, p = 0.08, n = 4).
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Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis.
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