Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.

There was a slight trend toward reduced bacterial burden in the C57BL/6 mice depleted of B cells ( Figure 2B ) as well as increased control in the spleens of B cell deficient mice ( Figure 1H ) [21] .

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We found however that while there was a very modest trend towards reduced bacterial burden in the lung, this did not reach statistical significance and was not seen at all in the spleen.

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