Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia.

Mean age differences across groups did not reach statistical significance (F(3,108)=1.904, p=0.133).

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Importantly, a highly significant diagnosis-by-genotype interaction localized to a large lateral prefrontal cortex (PFC) region ( Table 1 ): whereas healthy Val homozygotes showed a significant positive relationship between resting hippocampal and prefrontal rCBF, healthy Met carriers had a trend for an inverse relationship between these regions; in contrast, patients evidenced the opposite pattern, with Met carriers, but not Val homozygotes, demonstrating a strong positive hippocampal-PFC relationship ( Figure 2 ).

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