Emerging Therapeutic Options for the Management of COPD.

Clin Med Insights Circ Respir Pulm Med · 2013 · PMC3629926 · PMID 23641160

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did not reach statistical significanceno p-value reported

Rates of exacerbations were not as remarkable as demonstrated in the Calverley studies, which were numerically lower in the roflumilast arm than the comparator arm but did not reach statistical significance.

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