Barely Significant
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Evolution of foot-and-mouth disease virus intra-sample sequence diversity during serial transmission in bovine hosts.

Vet Res · 2013 · PMC3630017 · PMID 23452550

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a strong trendno p-value reported
Analysis conducted with mutation spectra, at the host-to-host scale, also showed a strong trend in dN/dS towards an increased purifying selective pressure along the chain.

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