However, there is an important trend suggesting an impairment in BTBR mice: BTBR mice made nearly double the total number of errors in learning the initial discrimination, when compared to C57 mice (BTBR: 68.2±13.8; C57∶39.3±5.6; p = 0.068).
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The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortex.
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