Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.

PLoS One · 2013 · PMC3636229 · PMID 23637927

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hedged sentences

0.0600

closest p · 1.2× alpha

0.1900

boldest claim

The sentences

showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

After adjustment for BMI, basal FNDC5 expression was positively associated with fasting insulin levels (p = 0.0326, Figure 4F ) and showed a trend towards positive association with HOMA-IR (p = 0.06).

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a weak trendp = 0.19not close (p > 0.1)

Even though there was a weak trend for association of the insulin-desensitizing minor A-allele of FNDC5 SNP rs726344 with higher FNDC5 mRNA contents (p = 0.19), this SNP’s MAF was too low to allow a reliable evaluation (only four heterozygous and no homozygous carriers of the minor allele were present among the myotube donors).

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