Place of preoperative treatment of acromegaly with somatostatin analog on surgical outcome: a systematic review and meta-analysis.

Regression analysis of the cured percentage in untreated patients versus the odds ratio of the ten studies analyzed and presented in table S2, revealed a highly significant linear relationship (Spearman Rho = −0.842, adjusted R2 = 0.806, P<0.0001) indicating that centers with good surgical results do not benefit from pretreatment and centers with worse surgical results benefit most from pretreatment.

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In this analysis, although there was a clear trend towards an improvement in the cure rate, the results show a positive borderline significant effect.

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The treatment shows a borderline significant effect, with a pooled OR (random effects) for biochemical cure of 1.62 (95% CI, 0.93–2.82).

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