Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage.

In our WT mouse model, when TNF-blocking antibodies were administered 1 hr after systemic infection was initiated by intra-peritoneally injection, the average Evans blue dye leakage and hematocrit values were lower; however, this did not reach statistical significance ( Figure 4A ).

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