Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination.

Of 17,566 detected genes, we identified 1,080 highly significant differentially expressed genes upon viral stimulation (p<1.00E −15 , FDR<1.00E −14 ), including various immune function and inflammation-related genes, genes involved in cell signaling, cell regulation and transcription, and genes with unknown function.

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3A , the number of mRNA-Seq rubella virus-specific sequences was higher in the high antibody responders (mean 22,856 reads, 0.18% of all reads) compared to the low antibody responders (mean 18,263 reads, 0.14% of all reads), although this observed difference did not reach statistical significance (p = 0.08).

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