Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.

Hence expression differences with control may be significant underestimations of the actual differences of each gene in the eye disc parts in the different genotypes.

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Nevertheless, the qRT-PCR comparisons between the different genotypes showed a trend in boi and ihog expression response to Dl overexpression that explains the cooperation between the miR-7 and Dl signalling, since there is the concomitant downregulation of the two functionally redundant Hh receptor genes, ihog and boi .

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