Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain.

The trypsin-like and caspase-like activities of 20S and 26S proteasomes were also diminished in the brain components of aged rats but due to high individual variations did not reach statistical significance with the exception of the 20S proteasome caspase-like activity in cerebellum ( Fig. 2 ).

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