Phenotypical studies In human atresia, the proportion of ChAT-IR myenteric neurons was higher in the proximal (38±16%) than distal segments (25±12%), although the difference did not reach statistical significance (n = 8; p = 0.31; figures 9A,B ) whereas ChAT mRNA expression was significantly higher in the proximal than distal segment (2.5-fold, p<0.05).
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Prenatal intestinal obstruction affects the myenteric plexus and causes functional bowel impairment in fetal rat experimental model of intestinal atresia.
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