MMP-7 mRNA showed no significant increase (fold change) in PBEC(A) for any of the stimulations [IL-9 stimulated: mean 1.7 (SD 1.4); IL-9/IL-13 combination: mean 2.2 (SD 2.0); IL-13 stimulation: mean 2.6 (SD 3.2)] however all stimulations showed a trend for increase ( Figure 5B ).
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Chronic IL9 and IL-13 exposure leads to an altered differentiation of ciliated cells in a well-differentiated paediatric bronchial epithelial cell model.
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