Alpha-toxin production tended to be higher in CA-MRSA than in HA-MRSA strains, but this difference did not reach statistical significance (median and IQR, 5153 ng/mL [1790-7683] vs. 2310 ng/mL [36–4326], respectively; P = 0.074, two-tailed Mann-Whitney U -test; Figure 4A and Table S1 ).
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PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts.
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0.0740