Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors.

In the merged dataset, 58 metabolites distinguished between HIV subjects and controls (FC>1.3, p<0.05, FDR<10%), including the 35 signature metabolites and 23 additional metabolites that approached significance in the initial and validation cohorts (0.05<p<0.20).

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