Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.

PLoS One · 2013 · PMC3659045 · PMID 23700419

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In line with the aforementioned reduction in iNOS expression by Sgpl1 −/− macrophages in vitro , a strong trend was observed towards decreased iNOS content in lesions of Sgpl1 −/− chimeras ( Figure 7C ).

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