Clinically significant interactions between antiretroviral and co-prescribed drugs for HIV-infected children: profiling and comparison of two drug databases.

26 The 189 (31.7%) DDIs rated as contraindications ( category X) by the Medscape database (NVP + artemisininbased combination therapy and EFV + artemisinin-based combination therapy), and the 45 (7.6%) DDIs rated as moderately significant interactions (LPVr + artemisinin/amodiaquine; LPVr + artemisinin-based combination therapy; LPVr + proguanil; LPVr [solution] + metronidazole; and EFV + loratadine) that required therapy monitoring, were rated as category A by the MIMS database.

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