Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets.

Fasting blood glucose levels and insulinemia and HbA 1c were significantly increased in HFD-fed LGALS3 −/− mice compared with other experimental groups at both 11 and 18 weeks, whereas in WT mice on HFD versus LFD at 18 weeks, the differences did not reach statistical significance ( Fig. 1 C and D ).

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